Between December 2020 and March 2021, the European Medicines Agency approved several vaccines on the basis of randomized, blinded, controlled trials: two messenger RNA-based vaccines—Comirnaty, BNT162b2 (Pfizer–BioNTech) and Spikevax, mRNA-1273 (Moderna)—both encoding the spike protein of SARS-CoV-2 encapsulated in lipid nanoparticles as the antigen and two vaccines based on recombinant adenoviruses

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